Article
Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked.
Cancer research - 1 Mar 1990
Karran P, Stephenson C, Macpherson P, Cairns-Smith S, Priestley A
Abstract excerpt
The loss of expression of the enzyme O6-methylguanine-DNA methyltransferase (the Mex- phenotype), which often results from cellular transformation, confers hypersensitivity to alkylating agents. We have observed two unrelated examples in which human cell lines have undergone a spontaneous alteration in their Mex phenotype during propagation in vitro. The change was reversible and was not the result of mutation....
Topics
- Adenosine Triphosphatases
- Cell Line
- Galactokinase
- Gene Expression Regulation, Enzymologic
- Genetic Linkage
- Humans
- Methyltransferases
- O(6)-Methylguanine-DNA Methyltransferase
- Phenotype
- Thymidine Kinase