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Article

Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked.

Cancer research - 1 Mar 1990

Karran P, Stephenson C, Macpherson P, Cairns-Smith S, Priestley A

Abstract excerpt

The loss of expression of the enzyme O6-methylguanine-DNA methyltransferase (the Mex- phenotype), which often results from cellular transformation, confers hypersensitivity to alkylating agents. We have observed two unrelated examples in which human cell lines have undergone a spontaneous alteration in their Mex phenotype during propagation in vitro. The change was reversible and was not the result of mutation....

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Source

Identifiers

PMID: 2137369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked.PMID 2137369Read ↗

Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in Mex- human cells.Semantic proximity Read ↗

cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells.Semantic proximity Read ↗

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Expression of the human MGMT O6-methylguanine DNA methyltransferase gene in a yeast alkylation-sensitive mutant: its effects on both exogenous and endogenous DNA alkylation damage.Semantic proximity Read ↗

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Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells.Semantic proximity Read ↗

Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cellsSemantic proximity Read ↗

Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.Semantic proximity Read ↗

Complementation of mismatch repair gene defects by chromosome transfer.Semantic proximity Read ↗

A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.Semantic proximity Read ↗

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents.Semantic proximity Read ↗

Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex-.Semantic proximity Read ↗

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