Article
Involvement of DNA topoisomerase II in the selective resistance of a mammalian cell mutant to DNA minor groove ligands: ligand-induced DNA-protein crosslinking and responses to topoisomerase poisons.
Carcinogenesis - 1 Apr 1990
Smith P J, Bell S M, Dee A, Sykes H
Abstract excerpt
A mutant murine cell line has previously been reported to be resistant to the AT-specific DNA minor groove ligand 2',5'-bi-1H-benzimidazole, 2',(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl), trichloride (Ho33342), due to an enhanced capacity to remove ligand molecules from cellular DNA via a pathwa...
Topics
- Amsacrine
- Animals
- Anthramycin
- Benzimidazoles
- Benzodiazepinones
- Cell Line
- Cell Survival
- DNA
- DNA Damage
- DNA Topoisomerases, Type II
- Distamycins
- Doxorubicin
- Drug Resistance
- Intercalating Agents
- Ligands
- Mice
- Mitoxantrone
- Mutation