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Article

Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells.

Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2001

Davis B M, Encell L P, Zielske S P, Christians F C, Liu L, Friebert S E, Loeb L A, Gerson S L

Abstract excerpt

Applied molecular evolution is a rapidly developing technology that can be used to create and identify novel enzymes that nature has not selected. An important application of this technology is the creation of highly drug-resistant enzymes for cancer gene therapy. Seventeen O(6)-alkylguanine-DNA alkyltransferase (AGT) mutants highly resistant to O(6)-benzylguanine (BG) were identified previously by screening 8...

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Identifiers

PMID: 11296271
DOI: 10.1073/pnas.091601198
PMCID: PMC33144

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells.PMID 11296271Read ↗

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