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Article

An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.

Genetics - 1 Feb 1998

Tissenbaum H A, Ruvkun G

Abstract excerpt

Mutations in daf-2 and age-1 cause a dramatic increase in longevity as well as developmental arrest at the dauer diapause stage in Caenorhabditis elegans. daf-2 and age-1 encode components of an insulin-like signaling pathway. Both daf-2 and age-1 act at a similar point in the genetic epistasis p...

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Identifiers

PMID: 9504918
DOI: 10.1093/genetics/148.2.703
PMCID: PMC1459840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9504918-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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