Article
Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance.
Diabetologia - 1 Oct 1997
Urhammer S A, Dalgaard L T, Sørensen T I, Møller A M, Andersen T, Tybjaerg-Hansen A, Hansen T, Clausen J O, Vestergaard H, Pedersen O
Abstract excerpt
Recently, a gene encoding a novel human uncoupling protein, designated UCP2, was discovered. The murine UCP2 was mapped to a region on mouse chromosome 7 which in several models has been shown to be linked to obesity and hyperinsulinaemia. Single strand conformation polymorphism (SSCP) analysis and direct sequencing of the coding region of the UCP2 gene in 35 obese Caucasian NIDDM patients of Danish ancestry...
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