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Article

No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure.

European journal of endocrinology - 1 Aug 1998

Klannemark M, Orho M, Groop L

Abstract excerpt

OBJECTIVE: The uncoupling protein 2 (UCP2) uncouples respiration from the oxidative phosphorylation in most cell types, predominantly in white fat and skeletal muscle. Since a decreased basal metabolic rate (BMR) would increase the susceptibility to weight gain, genetic alterations in the UCP2 gene could contribute to the pathogenesis of obesity and the metabolic syndrome (MSDR). DESIGN AND METHODS: To test this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9724080
DOI: 10.1530/eje.0.1390217

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure.PMID 9724080Read ↗

An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes.Semantic proximity Read ↗

Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians.Semantic proximity Read ↗

Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children.Semantic proximity Read ↗

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.Semantic proximity Read ↗

Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.Semantic proximity Read ↗

Lack of association between UCP2 gene polymorphisms and obesity phenotype in Italian Caucasians.Semantic proximity Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)Semantic proximity Read ↗

Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.Semantic proximity Read ↗

Mutational analysis of the UCP2 core promoter and relationships of variants with obesity.Semantic proximity Read ↗

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.Semantic proximity Read ↗

Analysis of the uncoupling protein-1 (UCP1) gene in obese and lean subjects: identification of four amino acid variants.Semantic proximity Read ↗

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