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Article

Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.

Diabetologia - 1 Feb 1998

Urhammer S A, Dalgaard L T, Sørensen T I, Tybjaerg-Hansen A, Echwald S M, Andersen T, Clausen J O, Pedersen O

Abstract excerpt

Uncoupling proteins (UCPs) are mitochondrial transporters that uncouple the cellular respiration releasing stored energy as heat. Recently a third member of the UCP family was identified. Human UCP3 is different from UCP1 and UCP2 by its high and preferential expression in skeletal muscle and consequently the UCP3 gene is an attractive candidate gene for obesity. In this study we have determined the intron/exon...

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Source

Identifiers

PMID: 9498661
DOI: 10.1007/s001250050897

Genes

UCP3
UCP1
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.PMID 9498661Read ↗

Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.Semantic proximity Read ↗

Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance.Semantic proximity Read ↗

The influence of six polymorphisms of uncoupling protein 3 (UCP3) gene and childhood obesity: a case-control study.Semantic proximity Read ↗

A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population.Semantic proximity Read ↗

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population.Semantic proximity Read ↗

Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin.Semantic proximity Read ↗

Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.Semantic proximity Read ↗

Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity.Semantic proximity Read ↗

Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study.Semantic proximity Read ↗

Genomic organization and mutational analysis of the human UCP2 gene, a prime candidate gene for human obesity.Semantic proximity Read ↗

Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.Semantic proximity Read ↗

Analysis of the uncoupling protein-1 (UCP1) gene in obese and lean subjects: identification of four amino acid variants.Semantic proximity Read ↗

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