Article
Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.
Life sciences - 1 Jan 1999
Tu N, Chen H, Winnikes U, Reinert I, Marmann G, Pirke K M, Lentes K U
Abstract excerpt
Uncoupling proteins (UCPs) are mitochondrial membrane transporters which are involved in dissipating the proton electrochemical gradient thereby releasing stored energy as heat. This implies a major role of UCPs in energy metabolism and thermogenesis which when deregulated are key risk factors for the development of obesity and other eating disorders. From the three different human UCPs identified so far by gene...
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