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Article

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.

American journal of physiology. Endocrinology and metabolism - 1 Jan 2004

Wang Hua, Chu Winston S, Lu Tong, Hasstedt Sandra J, Kern Philip A, Elbein Steven C

Abstract excerpt

The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance, and impaired beta-cell function. Uncoupling protein-2 (UCP2) is a widely expressed inner mitochondrial membrane protein. Common polymorphisms of the UCP2 gene have been implicated in diabetes, in obesity, and with cha...

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Source

Identifiers

PMID: 12915397
DOI: 10.1152/ajpendo.00231.2003

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12915397-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.PMID 12915397Read ↗

Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)Semantic proximity Read ↗

The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.Semantic proximity Read ↗

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.Semantic proximity Read ↗

Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.Semantic proximity Read ↗

Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians.Semantic proximity Read ↗

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.Semantic proximity Read ↗

A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.Semantic proximity Read ↗

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.Semantic proximity Read ↗

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.Semantic proximity Read ↗

UCP 2 gene polymorphisms in obesity and diabetes, and the role of UCP 2 in cancerSemantic proximity Read ↗

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism - 866 G/A in the promoter region is associated with type 2 diabetes mellitus among Kashmiri population of Northern India.Semantic proximity Read ↗

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