Article
Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes.
Clinical biochemistry - 1 May 2005
Larsen Lesli H, Gjesing Anette P, Sørensen Thorkild I A, Hamid Yasmin H, Echwald Søren M, Toubro Søren, Black Eva, Astrup Arne, Hansen Torben, Pedersen Oluf
Abstract excerpt
OBJECTIVE: To investigate the preproghrelin gene for variants and their association with obesity and type 2 diabetes. DESIGN AND METHOD: 82 obese probands were analyzed for mutations using single-strand conformational polymorphism, heteroduplex analyses and sequencing. Association studies were performed in 234 juvenile-onset obese and 323 lean men and in 557 type 2 diabetic and 233 glucose tolerant subjects....
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