An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes.

doi:10.1007/s001250051216

Article

An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes.

Diabetologia - 1 Jun 1999

Cassell P G, Neverova M, Janmohamed S, Uwakwe N, Qureshi A, McCarthy M I, Saker P J, Albon L, Kopelman P, Noonan K, Easlick J, Ramachandran A, Snehalatha C, Pecqueur C, Ricquier D, Warden C, Hitman G A

Abstract excerpt

AIMS/HYPOTHESIS: Linkage between markers close to the uncoupling protein 2 and 3 genes (11q13) and resting metabolic rate and a pre-diabetic phenotype have been found. The syntenic region in mouse has been found to be linked to quantitative traits associated with obesity and diabetes. UCP2 and UCP3 could therefore have an important role in body weight regulation and susceptibility to diabetes. We investigated a...

Topics

Adult
Animals
Body Mass Index
Body Weight
Diabetes Mellitus, Type 2
Electrophoresis, Agar Gel
Exons
Female
Genetic Predisposition to Disease
Humans

India

Ion Channels

Male

Membrane Transport Proteins

Mice

Middle Aged

Mitochondrial Proteins

Proteins

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