Article
Mutational analysis of the UCP2 core promoter and relationships of variants with obesity.
Obesity research - 1 Nov 2003
Dalgaard Louise T, Andersen Gitte, Larsen Lesli H, Sørensen Thorkild I A, Andersen Teis, Drivsholm Thomas, Borch-Johnsen Knut, Fleckner Jan, Hansen Torben, Din Nanni, Pedersen Oluf
Abstract excerpt
OBJECTIVE: To identify polymorphisms in the human uncoupling protein 2 gene (UCP2) promoter and to investigate whether these were associated with obesity or weight gain. RESEARCH METHODS AND PROCEDURES: The human UCP2 promoter was characterized by reporter gene analysis in cell lines derived from skeletal muscle, white adipose tissue, and embryonic tissue. We analyzed the core promoter for polymorphisms in 60...
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