Article
Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting after axotomy but not axon regeneration into growth-permissive transplants.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 1997
Buffo A, Holtmaat A J, Savio T, Verbeek J S, Oberdick J, Oestreicher A B, Gispen W H, Verhaagen J, Rossi F, Strata P
Abstract excerpt
B-50/GAP-43 is a nervous tissue-specific protein, the expression of which is associated with axon growth and regeneration. Its overexpression in transgenic mice produces spontaneous axonal sprouting and enhances induced remodeling in several neuron populations (; ). We examined the capacity of th...
Topics
- Animals
- Axons
- Axotomy
- Cell Death
- GAP-43 Protein
- Gene Expression
- Heterozygote
- Mice
- Mice, Transgenic
- Nerve Regeneration
- Neurites
- Phenotype
- Promoter Regions, Genetic
- Purkinje Cells