Article
Axon regeneration in young adult mice lacking Nogo-A/B.
Neuron - 24 Apr 2003
Kim Ji Eun, Li Shuxin, GrandPré Tadzia, Qiu Dike, Strittmatter Stephen M
Abstract excerpt
After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no abnormality in...
Topics
- Animals
- Axons
- Axotomy
- Brain
- Female
- Fetal Viability
- Male
- Mice
- Mice, Knockout
- Motor Activity
- Myelin Proteins
- Myelin Sheath
- Nerve Regeneration
- Nogo Proteins
- Phenotype
- Pyramidal Tracts
- Recovery of Function
- Spatial Behavior