Article
Axon regeneration in young adult mice lacking Nogo-A/B.
Neuron - 24 Apr 2003
Kim Ji Eun, Li Shuxin, GrandPré Tadzia, Qiu Dike, Strittmatter Stephen M
Abstract excerpt
After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no abnormality in...
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