Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Temporal Expression of Mutant TDP-43 Correlates with Early Amyotrophic Lateral Sclerosis Phenotype and Motor Weakness.

Current neurovascular research - 1 Jan 2018

Chen Qihua, Zhou Jinxia, Huang Cao, Huang Bo, Bi Fangfang, Zhou Hongxia, Xiao Bo

Abstract excerpt

BACKGROUND: Mutant transactive response DNA-binding protein (TDP-43) is closely correlated to the inherited form of amyotrophic lateral sclerosis (ALS). TDP-43 transgenic rats can reproduce the core phenotype of ALS and constitutive expression of TDP-43 caused postnatal death. OBJECTIVE: The study aimed to understand whether neurologic deficiency caused by mutant TDP- 43 is dependent on its temporal expression....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Muscle Weakness

Share to Rats, Sprague-Dawley

Share to Rats, Transgenic

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29313467
DOI: 10.2174/1567202615666180109161541
PMCID: PMC5997843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Temporal Expression of Mutant TDP-43 Correlates with Early Amyotrophic Lateral Sclerosis Phenotype and Motor Weakness.PMID 29313467Read ↗

Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in ratsSemantic proximity Read ↗

Loss of TDP-43 causes age-dependent progressive motor neuron degenerationSemantic proximity Read ↗

Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in miceSemantic proximity Read ↗

Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.Semantic proximity Read ↗

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in miceSemantic proximity Read ↗

Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 MiceSemantic proximity Read ↗

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.Semantic proximity Read ↗

Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.Semantic proximity Read ↗

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragmentsSemantic proximity Read ↗

Progressive motor weakness in transgenic mice expressing human TDP-43Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.