Article
Neurites regrowth of cortical neurons by GSK3beta inhibition independently of Nogo receptor 1.
Journal of neurochemistry - 1 Jun 2010
Seira Oscar, Gavín Rosalina, Gil Vanessa, Llorens Franc, Rangel Alejandra, Soriano Eduardo, del Río José Antonio
Abstract excerpt
Lesioned axons do not regenerate in the adult mammalian CNS, owing to the over-expression of inhibitory molecules such as myelin-derived proteins or chondroitin sulphate proteoglycans. In order to overcome axon inhibition, strategies based on extrinsic and intrinsic treatments have been developed. For myelin-associated inhibition, blockage with NEP1-40, receptor bodies or IN-1 antibodies has been used. In...
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