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Article

Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats

12 Dec 2011

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration, which ultimately leads to paralysis and death. Mutation of TAR DNA binding protein 43 (TDP-43) has been linked to the development of an inherited form of ALS. Existing TDP-43 transgenic animals develop a limited loss of motor neurons and therefore do not faithfully reproduce the core phenotype of ALS. Here, we report...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22156203
DOI: 10.1172/jci59130

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Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in ratsPMID 22156203Read ↗

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