Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Grafting neural precursor cells promotes functional recovery in an SCA1 mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Oct 2009

Chintawar Satyan, Hourez Raphael, Ravella Ajay, Gall David, Orduz David, Rai Myriam, Bishop Don Patrick, Geuna Stefano, Schiffmann Serge N, Pandolfo Massimo

Abstract excerpt

The B05 transgenic SCA1 mice, expressing human ataxin-1 with an expanded polyglutamine tract in cerebellar Purkinje cells (PCs), recapitulate many pathological and behavioral characteristics of the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1), including progressive ataxia and PC loss. We transplanted neural precursor cells (NPCs) derived from the subventricular zone of GFP-expressing adult mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adult Stem Cells
Share to Ataxin-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ataxins

Share to Cerebral Ventricles

Share to Dendrites

Share to Hand Strength

Share to Recovery of Function

Share to Stem Cell Transplantation

Source

Open in PubMed Open full text

Identifiers

PMID: 19846700
DOI: 10.1523/JNEUROSCI.0647-09.2009
PMCID: PMC6665209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Grafting neural precursor cells promotes functional recovery in an SCA1 mouse model.PMID 19846700Read ↗

Cerebellar Allografts Survive and Transiently Alleviate Ataxia in a Transgenic Model of Spinocerebellar Ataxia Type-1Semantic proximity Read ↗

Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1Semantic proximity Read ↗

Mutant Ataxin-1 Inhibits Neural Progenitor Cell Proliferation in SCA1.Semantic proximity Read ↗

Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1.Semantic proximity Read ↗

Development and Characterization of Self-Tracing Neural Progenitor Cells for Mapping Their Synaptic Integration into Endogenous Neural NetworksSemantic proximity Read ↗

Organization and histochemical phenotype of human fetal cerebellar cells following transplantation into the cerebellum of nude mice.Semantic proximity Read ↗

AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC diseaseSemantic proximity Read ↗

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in miceSemantic proximity Read ↗

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.Semantic proximity Read ↗

Amelioration of the behavioral phenotype in genetically ataxic mice through bilateral intracerebellar grafting of fetal Purkinje cells.Semantic proximity Read ↗

Intracerebellar transplantation of neural stem cells into mice with neurodegeneration improves neuronal networks with functional synaptic transmission.Semantic proximity Read ↗

Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.