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Article

Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.

International journal of molecular sciences - 11 Nov 2023

Huang Bo, Liu Xionghao, Zhang Tingting, Wu Qinxue, Huang Cao, Xia Xu-Gang, Zhou Hongxia

Abstract excerpt

A dominant mutation in hnRNPA1 causes amyotrophic lateral sclerosis (ALS), but it is not known whether this mutation leads to motor neuron death through increased or decreased function. To elucidate the relationship between pathogenic hnRNPA1 mutation and its native function, we created novel transgenic rats that overexpressed wildtype rat hnRNPA1 exclusively in motor neurons. This targeted expression of wildtype...

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Identifiers

PMID: 38003404
DOI: 10.3390/ijms242216214
PMCID: PMC10671660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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