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Article

TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain

30 Dec 2013

Abstract excerpt

Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Although recent studies have revealed that mutant TDP-43 in neuronal and glial cells is toxic, how mutant TDP-43 causes primarily neuronal degeneration in an age-dependent manner remains unclear. Using adeno-associated virus (AAV) that expresses mutant TDP-43...

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PMID: 24381309
DOI: 10.1093/hmg/ddt662

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