Transplanted neurons alter the course of neurodegenerative disease in Lurcher mutant mice.

doi:10.1006/exnr.1998.6960

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Article

Transplanted neurons alter the course of neurodegenerative disease in Lurcher mutant mice.

Experimental neurology - 1 Dec 1998

Heckroth J A, Hobart N J, Summers D

Abstract excerpt

Embryonic cerebellar, neocortical, and striatal tissues derived from NSE-LacZ transgenic mice were transplanted into the right cerebellar hemisphere of 8- to 10-day-old Lurcher or wild-type mice. Host mice survived for 30-90 days and the transplanted tissue was examined by light microscopy using...

Topics

Animals
Ataxia
Brain Tissue Transplantation
Cell Count
Cerebellum
Corpus Striatum
Female
Fetal Tissue Transplantation
Genetic Markers
Lac Operon
Male
Mice
Mice, Neurologic Mutants
Neocortex
Nerve Degeneration
Neurodegenerative Diseases
Olivary Nucleus
Phenotype

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