Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases.

Open biology - 1 Aug 2016

Alvaro-Benito Miguel, Morrison Eliot, Wieczorek Marek, Sticht Jana, Freund Christian

Abstract excerpt

Classical MHC class II (MHCII) proteins present peptides for CD4(+) T-cell surveillance and are by far the most prominent risk factor for a number of autoimmune disorders. To date, many studies have shown that this link between particular MHCII alleles and disease depends on the MHCII's particular ability to bind and present certain peptides in specific physiological contexts. However, less attention has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Autoimmune Diseases
Share to Gene Editing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to HLA-D Antigens

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 27534821
DOI: 10.1098/rsob.160165
PMCID: PMC5008016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases.PMID 27534821Read ↗

Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.Semantic proximity Read ↗

Revisiting nonclassical HLA II functions in antigen presentation: Peptide editing and its modulation.Semantic proximity Read ↗

Editing of the HLA-DR-peptide repertoire by HLA-DM.Semantic proximity Read ↗

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.Semantic proximity Read ↗

A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.Semantic proximity Read ↗

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchangeSemantic proximity Read ↗

Tuning DO:DM ratios modulates MHC class II immunopeptidomesSemantic proximity Read ↗

HLA variation and disease.Semantic proximity Read ↗

On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.Semantic proximity Read ↗

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.Semantic proximity Read ↗

Human MHC architecture and evolution: implications for disease association studies.Semantic proximity Read ↗

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.