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Article

Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form.

The Journal of cell biology - 3 Nov 1997

Beinhauer J D, Hagan I M, Hegemann J H, Fleig U

Abstract excerpt

Through a screen designed to isolate novel fission yeast genes required for chromosome segregation, we have identified mal3+. The mal3-1 mutation decreased the transmission fidelity of a nonessential minichromosome and altered sensitivity to microtubule-destabilizing drugs. Sequence analysis reve...

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Source

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Identifiers

PMID: 9348288
DOI: 10.1083/jcb.139.3.717
PMCID: PMC2141698

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9348288-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form.PMID 9348288Read ↗

The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.Semantic proximity Read ↗

A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules.Semantic proximity Read ↗

Proper microtubule structure is vital for timely progression through meiosis in fission yeast.Semantic proximity Read ↗

Fission yeast mal2+ is required for chromosome segregation.Semantic proximity Read ↗

Genome-wide synthetic lethal screens identify an interaction between the nuclear envelope protein, Apq12p, and the kinetochore in Saccharomyces cerevisiae.Semantic proximity Read ↗

APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.Semantic proximity Read ↗

The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.Semantic proximity Read ↗

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.Semantic proximity Read ↗

The APC-EB1 interaction.Semantic proximity Read ↗

Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.Semantic proximity Read ↗

The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Semantic proximity Read ↗

Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.Semantic proximity Read ↗

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