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Article

The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.

Developmental cell - 1 Jul 2005

Jin Ye, Mancuso Joel J, Uzawa Satoru, Cronembold Daniela, Cande W Zacheus

Abstract excerpt

Centrosome aberrations caused by misregulated centrosome maturation result in defective spindle and genomic instability. Here we report that the fission yeast homolog of the human transcription factor EAP30, Dot2, negatively regulates meiotic spindle pole body (SPB, the yeast equivalent of centrosome) maturation. dot2 mutants show excess electron-dense material accumulating near SPBs, which we refer to as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15992541
DOI: 10.1016/j.devcel.2005.04.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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