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Article

A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules.

Experimental cell research - 1 Feb 2012

Iimori Makoto, Ozaki Kanako, Chikashige Yuji, Habu Toshiyuki, Hiraoka Yasushi, Maki Takahisa, Hayashi Ikuko, Obuse Chikashi, Matsumoto Tomohiro

Abstract excerpt

Mal3 is a fission yeast homolog of EB1, a plus-end tracking protein (+TIP). We have generated a mutation (89R) replacing glutamine with arginine in the calponin homology (CH) domain of Mal3. Analysis of the 89R mutant in vitro has revealed that the mutation confers a higher affinity to microtubules and enhances the intrinsic activity to promote the microtubule-assembly. The mutant Mal3 is no longer a +TIP, but...

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PMID: 22134091
DOI: 10.1016/j.yexcr.2011.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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