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Article

Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.

Current biology : CB - 10 Jul 2001

Nakamura M, Zhou X Z, Lu K P

Abstract excerpt

Human EB1 was originally cloned as a protein that interacts with the COOH terminus of adenomatous polyposis coli (APC). Interestingly, this interaction is often disrupted in colon cancer, due to mutations in APC. EB1 also interacts with the plus-ends of microtubules and targets APC to microtubule tips. Since APC is detected on the kinetochores of chromosomes, it has been hypothesized that the EB1-APC interaction...

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Source

Identifiers

PMID: 11470413
DOI: 10.1016/s0960-9822(01)00297-4

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.PMID 11470413Read ↗

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