Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.

The EMBO journal - 2 Jul 2001

Garcia M A, Vardy L, Koonrugsa N, Toda T

Abstract excerpt

The TOG/XMAP215-related proteins play a role in microtubule dynamics at its plus end. Fission yeast Alp14, a newly identified TOG/XMAP215 family protein, is essential for proper chromosome segregation in concert with a second homologue Dis1. We show that the alp14 mutant fails to progress towards normal bipolar spindle formation. Intriguingly, Alp14 itself is a component of the Mad2-dependent spindle checkpoint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetochores

Share to Microtubule-Associated Proteins

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Spindle Apparatus

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11432827
DOI: 10.1093/emboj/20.13.3389
PMCID: PMC125509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.PMID 11432827Read ↗

CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.Semantic proximity Read ↗

Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.Semantic proximity Read ↗

Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.Semantic proximity Read ↗

TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.Semantic proximity Read ↗

mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila.Semantic proximity Read ↗

Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast.Semantic proximity Read ↗

An extended anaphase signaling pathway for Mad2p includes microtubule organizing center proteins and multiple motor-dependent transitions.Semantic proximity Read ↗

The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.Semantic proximity Read ↗

Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.Semantic proximity Read ↗

The mitotic spindle is required for loading of the DASH complex onto the kinetochore.Semantic proximity Read ↗

Protein complexes at the microtubule organizing center regulate bipolar spindle assembly.Semantic proximity Read ↗

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.