Article
The APC-EB1 interaction.
Advances in experimental medicine and biology - 1 Jan 2009
Morrison Ewan E
Abstract excerpt
Changes in cell proliferation seen in cancers initiated by adenomatous polyposis coli (APC) gene mutation are driven by the loss of an ability to negatively regulate the canonical WNT signalling pathway. However, mutant APC proteins also lack the ability to interact with a number of other ligands...
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