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Article

The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.

Molecular biology of the cell - 1 Dec 2004

Kerres Anne, Vietmeier-Decker Corina, Ortiz Jennifer, Karig Inga, Beuter Christoph, Hegemann Johannes, Lechner Johannes, Fleig Ursula

Abstract excerpt

A critical aspect of mitosis is the interaction of the kinetochore with spindle microtubules. Fission yeast Mal3 is a member of the EB1 family of microtubule plus-end binding proteins, which have been implicated in this process. However, the Mal3 interaction partner at the kinetochore had not been identified. Here, we show that the mal3 mutant phenotype can be suppressed by the presence of extra Spc7, an...

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Identifiers

PMID: 15371542
DOI: 10.1091/mbc.e04-06-0443
PMCID: PMC532008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.PMID 15371542Read ↗

The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Semantic proximity Read ↗

Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form.Semantic proximity Read ↗

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