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Article

Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci.

American journal of human genetics - 1 Oct 1992

Sribney W M, Swift M

Abstract excerpt

Sib-pair linkage analysis has been proposed for identifying genes that predispose to common diseases. We have shown that the presence of assortative mating and multiple disease-susceptibility loci (genetic heterogeneity) can increase the required sample size for affected-affected sib pairs several fold over the sample size required under random mating. We propose a new test statistic based on sib trios composed...

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Identifiers

PMID: 1415221
PMCID: PMC1682815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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