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Article

Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci.

American journal of human genetics - 1 Oct 1992

Sribney W M, Swift M

Abstract excerpt

Sib-pair linkage analysis has been proposed for identifying genes that predispose to common diseases. We have shown that the presence of assortative mating and multiple disease-susceptibility loci (genetic heterogeneity) can increase the required sample size for affected-affected sib pairs several fold over the sample size required under random mating. We propose a new test statistic based on sib trios composed...

Topics

Alleles
Crosses, Genetic
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genotype
Humans
Male
Mathematics
Models, Genetic
Models, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Probability

Source

Open in PubMed Open full text

Identifiers

PMID: 1415221
PMCID: PMC1682815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1415221-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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