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Article

Adenovirus-mediated hepatocyte nuclear factor-4alpha overexpression maintains liver phenotype in cultured rat hepatocytes.

Biochemical and biophysical research communications - 23 Sept 2005

Naiki Takafumi, Nagaki Masahito, Asano Takahiko, Kimata Takayuki, Moriwaki Hisataka

Abstract excerpt

Hepatocyte nuclear factor 4alpha (HNF-4alpha) is a transcription factor that controls embryonal liver development and that maintains and regulates gene expression in adult liver cells. We have previously demonstrated that transient overexpression of HNF-4alpha up-regulates a number of liver-specific genes in hepatoma cell lines. In this study, we extend these studies by assessing the functional role of HNF-4alpha...

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Identifiers

PMID: 16087161
DOI: 10.1016/j.bbrc.2005.07.102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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