Article
Both N-terminal myosin-binding and C-terminal actin-binding sites on smooth muscle caldesmon are required for caldesmon-mediated inhibition of actin filament velocity.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 1997
Wang Z, Jiang H, Yang Z Q, Chacko S
Abstract excerpt
It has been suggested that the tethering caused by binding of the N-terminal region of smooth muscle caldesmon (CaD) to myosin and its C-terminal region to actin contributes to the inhibition of actin-filament movement over myosin heads in an in vitro motility assay. However, direct evidence for this assumption has been lacking. In this study, analysis of baculovirus-generated N-terminal and C-terminal deletion...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.