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Article

Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine.

American journal of physiology. Heart and circulatory physiology - 1 May 2009

Wang Hong Hui, Nakamura Akio, Matsumoto Atsushi, Yoshiyama Shinji, Qin Xiaoran, Ye Li-Hong, Xie Ce, Zhang Yue, Gao Ying, Ishikawa Ryoki, Kohama Kazuhiro

Abstract excerpt

The actin-myosin interaction of vascular smooth muscle cells (VSMCs) is regulated by myosin light chain kinase (MLCK), which is a fusion protein of the central catalytic domain with the N-terminal actin-binding and C-terminal myosin-binding domains. In addition to the regulatory role of kinase activity mediated by the catalytic domain, nonkinase activity that derives from both terminals is able to exert a...

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PMID: 19234090
DOI: 10.1152/ajpheart.00965.2008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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