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Article

Amino acid mutations in the caldesmon COOH-terminal functional domain increase force generation in bladder smooth muscle.

American journal of physiology. Renal physiology - 15 Nov 2013

Deng Maoxian, Boopathi Ettickan, Hypolite Joseph A, Raabe Tobias, Chang Shaohua, Zderic Stephen, Wein Alan J, Chacko Samuel

Abstract excerpt

Caldesmon (CaD), a component of smooth muscle thin filaments, binds actin, tropomyosin, calmodulin, and myosin and inhibits actin-activated ATP hydrolysis by smooth muscle myosin. Internal deletions of the chicken CaD functional domain that spans from amino acids (aa) 718 to 731, which corresponds to aa 512-530 including the adjacent aa sequence in mouse CaD, lead to diminished CaD-induced inhibition of...

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Identifiers

PMID: 23986516
DOI: 10.1152/ajprenal.00174.2013
PMCID: PMC3840250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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