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Article

The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin.

The Journal of biological chemistry - 10 Aug 2001

Ikebe M, Komatsu S, Woodhead J L, Mabuchi K, Ikebe R, Saito J, Craig R, Higashihara M

Abstract excerpt

Myosin II self-assembles to form thick filaments that are attributed to its long coiled-coil tail domain. The present study has determined a region critical for filament formation of vertebrate smooth muscle and nonmuscle myosin II. A monoclonal antibody recognizing the 28 residues from the C-terminal end of the coiled-coil domain of smooth muscle myosin II completely inhibited filament formation, whereas other...

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Identifiers

PMID: 11395487
DOI: 10.1074/jbc.M101969200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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