Article
A long, weakly charged actin-binding loop is required for phosphorylation-dependent regulation of smooth muscle myosin.
The Journal of biological chemistry - 23 Oct 1998
Rovner A S
Abstract excerpt
Chimeric substitution of the weak actin-binding loop (ABL) from chicken skeletal muscle myosin for that of gizzard smooth muscle heavy meromyosin (HMM) causes activation of the dephosphorylated mutant (SABL HMM; Rovner, A. S., Freyzon, Y., and Trybus, K. M. (1995) J. Biol. Chem. 270, 30260-30263)...
Topics
- Actins
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Chickens
- Electricity
- Enzyme Activation
- Gizzard, Avian
- Molecular Sequence Data
- Movement
- Muscle, Skeletal
- Muscle, Smooth
- Mutation
- Myosin Subfragments
- Myosins
- Phosphorylation
- Protein Binding
- Protein Isoforms