Article
A long, weakly charged actin-binding loop is required for phosphorylation-dependent regulation of smooth muscle myosin.
The Journal of biological chemistry - 23 Oct 1998
Rovner A S
Abstract excerpt
Chimeric substitution of the weak actin-binding loop (ABL) from chicken skeletal muscle myosin for that of gizzard smooth muscle heavy meromyosin (HMM) causes activation of the dephosphorylated mutant (SABL HMM; Rovner, A. S., Freyzon, Y., and Trybus, K. M. (1995) J. Biol. Chem. 270, 30260-30263). The present study determined whether this loss of regulation is due to the greater positive charge density (5 versus...
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