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Article

Retinoic acid inhibits the growth of bone marrow mesenchymal stem cells and induces p27Kip1 and p16INK4A up-regulation.

Molecular and cellular biochemistry - 1 May 2003

Oliva Adriana, Borriello Adriana, Zeppetelli Stefania, Di Feo Angelo, Cortellazzi Pilade, Ventriglia Vega, Criscuolo Maria, Zappia Vincenzo, Della Ragione Fulvio

Abstract excerpt

The importance of bone marrow mesenchymal stem cells in hemopoiesis has been definitely demonstrated. Thus, their impairment might cause profound alteration on production and maturation of blood cells. In the present paper, we investigated, for the first time, the effect of retinoic acid, an important antileukemic molecule, on the proliferation of primary cultures of human bone marrow mesenchymal stem cells. We...

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PMID: 12841631
DOI: 10.1023/a:1024192719178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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