Article
Control of G1 arrest after DNA damage.
Environmental health perspectives - 1 Dec 1993
Kastan M B, Kuerbitz S J
Abstract excerpt
The temporal relationship between DNA damage and DNA replication may be critical in determining whether the genetic changes necessary for cellular transformation occur after DNA damage. Recent characterization of the mechanisms responsible for alterations in cell-cycle progression after DNA damage in our laboratory have implicated the p53 (tumor suppressor) protein in the G1 arrest that occurs after certain types...
Topics
- Animals
- DNA Damage
- DNA Replication
- G1 Phase
- Gamma Rays
- Genes, p53
- Humans
- Mutation