Article
Role of retinoblastoma gene product in p53-mediated DNA damage response.
Experimental cell research - 1 Dec 1994
Smith M L, Zhan Q, Bae I, Fornace A J
Abstract excerpt
The cellular response to DNA-damaging agents involves the activation of cell cycle checkpoints. Checkpoints provide a transient delay in cell cycle progression, presumably to allow time for the cell to repair the damage. A most important checkpoint, active in the G1 phase of the cell cycle, is me...
Topics
- Cell Cycle
- Cell Division
- Cell Line
- DNA Damage
- Genes, Retinoblastoma
- Genes, p53
- Humans
- Mutation
- Phosphorylation
- Retinoblastoma Protein
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53