Distinct effects of various p53 mutants on differentiation and viability of human K562 leukemia cells.

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Article

Distinct effects of various p53 mutants on differentiation and viability of human K562 leukemia cells.

Oncology research - 1 Jan 1997

Kremenetskaya O S, Logacheva N P, Baryshnikov A Y, Chumakov P M, Kopnin B P

Abstract excerpt

Mutations of the p53 tumor suppressor are often observed in various human tumors, including blast crisis of chronic myelogenous leukemia (CML). The pattern of p53 mutations in CML shows some peculiarities compared with majority of other malignancies. In particular, the substitutions at codon 273,...

Topics

Animals
Antigens, CD
Apoptosis
Cell Differentiation
Cell Survival
Culture Media
Genes, p53
Humans
Leukemia, Erythroblastic, Acute
Mice
Phenotype
Transfection
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9268986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9268986-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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