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Article

Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb.

Developmental biology - 15 Mar 2003

Adamska Maja, MacDonald Bryan T, Meisler Miriam H

Abstract excerpt

doubleridge is a transgene-induced mutation characterized by polydactyly and syndactyly of the forelimbs. The transgene insertion maps to the proximal region of chromosome 19. During embryonic development of the mutant forelimb, delayed elevation and compaction of the apical ectodermal ridge (AER) produces a ridge that is abnormally broad and flat. Fgf8 expression persists in the ventral forelimb ectoderm of the...

Topics

Animals
Apoptosis
Body Patterning
Chromosome Mapping
Ectoderm
Fibroblast Growth Factor 8
Fibroblast Growth Factors
Forelimb
Gene Expression Regulation, Developmental
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hedgehog Proteins

Homeodomain Proteins

In Situ Hybridization, Fluorescence

Male

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Mice, Transgenic

Source

Identifiers

PMID: 12648495
DOI: 10.1016/s0012-1606(02)00114-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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