Article
Immortalization of mutant p53-transfected human fibroblasts by treatment with either 4-nitroquinoline 1-oxide or X-rays.
In vitro cellular & developmental biology. Animal - 1 Sept 1997
Kino K, Fushimi K, Gao C, Shima T, Mihara K, Namba M
Abstract excerpt
The study of in vitro cell transformation is valuable for understanding the multistep carcinogenesis of human cells. The difficulty in inducing neoplastic transformation of human cells by treatment with chemical or physical agents alone is due to the difficulty in immortalizing normal human cells. Thus, the immortalization step is critical for in vitro neoplastic transformation of human cells. We transfected a...
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