Article
Mutation in p53 and de-regulation of p53-related gene expression in three human cell lines immortalized with 4-nitroquinoline 1-oxide or 60Co gamma rays.
International journal of cancer - 29 May 1996
Iijima M, Mihara K, Kondo T, Tsuji T, Ishioka C, Namba M
Abstract excerpt
In vitro models of malignant transformation of human cells may provide considerable insight into the mechanisms of multi-step carcinogenesis. It is well established that normal human cells must be immortalized before they can be malignantly transformed; however, they are stringently destined for...
Topics
- 4-Nitroquinoline-1-oxide
- Base Sequence
- Blotting, Northern
- CDC2 Protein Kinase
- Carcinogens
- Cell Line
- Cell Transformation, Neoplastic
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Down-Regulation
- Fibroblasts
- Gamma Rays
- Gene Expression Regulation, Neoplastic
- Genes, cdc