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Article

Molecular genetic approaches to the study of cellular senescence.

Mutation research - 1 Jan 2000

Ning Y, Pereira-Smith O M

Abstract excerpt

Normal cells in culture exhibit limited division potential, which is used as a model for cellular aging. In contrast, tumor-derived, carcinogen- or virus-transformed cells are capable of dividing indefinitely (immortal). Fusion of normal with immortal human cells yielded hybrids having limited life span, indicating that cellular senescence is a dominant phenotype and that immortality is recessive. Fusions of...

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PMID: 1722020
DOI: 10.1016/0921-8734(91)90021-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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