Article
Molecular genetic approaches to the study of cellular senescence.
Mutation research - 1 Jan 2000
Ning Y, Pereira-Smith O M
Abstract excerpt
Normal cells in culture exhibit limited division potential, which is used as a model for cellular aging. In contrast, tumor-derived, carcinogen- or virus-transformed cells are capable of dividing indefinitely (immortal). Fusion of normal with immortal human cells yielded hybrids having limited life span, indicating that cellular senescence is a dominant phenotype and that immortality is recessive. Fusions of...
Topics
- Animals
- Cell Line, Transformed
- Cellular Senescence
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 4
- Humans
- Hybrid Cells
- Mutation