Article
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Human cell - 1 Dec 1993
Namba M, Iijima M, Kondo T, Jahan I, Mihara K
Abstract excerpt
Three normal human fibroblast strains were immortalized by treatment with either 4-nitroquinoline 1-oxide (SUSM-1 and OUMS-24F lines) or 60Co gamma rays (KMST-6 line). Immortalization of normal human cells with these agents required repeated treatments. Before immortalization, most of the cells t...
Topics
- 4-Nitroquinoline-1-oxide
- Cell Line
- Cell Transformation, Neoplastic
- Cytological Techniques
- Fibroblasts
- Genes, p53
- Genes, ras
- Humans
- Mutation