Article
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Human cell - 1 Dec 1993
Namba M, Iijima M, Kondo T, Jahan I, Mihara K
Abstract excerpt
Three normal human fibroblast strains were immortalized by treatment with either 4-nitroquinoline 1-oxide (SUSM-1 and OUMS-24F lines) or 60Co gamma rays (KMST-6 line). Immortalization of normal human cells with these agents required repeated treatments. Before immortalization, most of the cells treated with these mutagenic agents showed more or less chromosome aberrations, but immortalized cells appeared very...
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