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Article

Mutation of p53 is not a prerequisite for immortalization of human fibroblasts by SV40 T antigen.

Experimental cell research - 15 Mar 1996

Moorwood K, Price T N, Mayne L V

Abstract excerpt

The in vitro life span of human cells is under genetic control and limited. Immortalized cells, however, can be obtained at a low frequency following expression of the SV40 T antigen gene though the steps that lead to immortality are not well understood. p53 has been implicated in cell cycle regulation and evidence suggests it may have a role in controlling life span in rodent and human cells. In this study, we...

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Identifiers

PMID: 8601408
DOI: 10.1006/excr.1996.0086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutation of p53 is not a prerequisite for immortalization of human fibroblasts by SV40 T antigen.PMID 8601408Read ↗

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