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Article

Mutation of p53 is not a prerequisite for immortalization of human fibroblasts by SV40 T antigen.

Experimental cell research - 15 Mar 1996

Moorwood K, Price T N, Mayne L V

Abstract excerpt

The in vitro life span of human cells is under genetic control and limited. Immortalized cells, however, can be obtained at a low frequency following expression of the SV40 T antigen gene though the steps that lead to immortality are not well understood. p53 has been implicated in cell cycle regu...

Topics

Antigens, Polyomavirus Transforming
Base Sequence
Cell Transformation, Viral
Cells, Cultured
Exons
Fibroblasts
Gene Rearrangement
Genes, p53
Humans
Molecular Sequence Data
Mutation
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simian virus 40

Skin

Source

Identifiers

PMID: 8601408
DOI: 10.1006/excr.1996.0086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8601408-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutation of p53 is not a prerequisite for immortalization of human fibroblasts by SV40 T antigen.PMID 8601408Read ↗

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