Article
[Aging and immortalization of human cells].
Human cell - 1 Dec 1994
Naniwa M, Kano Y, Iijima M, Kondo T, mihara K
Abstract excerpt
In vitro models of malignant transformation of human cells may provide considerable insight into the mechanisms of multistep carcinogenesis. It is well established that normal human cells must be immortalized before they are malignantly transformed, but normal human cells are extremely refractory...
Topics
- 4-Nitroquinoline-1-oxide
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cellular Senescence
- Cobalt
- Fibroblasts
- Gamma Rays
- Genes, p53
- Humans
- Mutation