Article
The cellular oncogene p53 can be activated by mutagenesis.
Nature - 1 Jan 2000
Jenkins J R, Rudge K, Chumakov P, Currie G A
Abstract excerpt
P53 is a cellular phosphoprotein of short half-life (t1/2) which is present at elevated levels in cells transformed by various stimuli including viruses, chemicals and radiation. p53 forms specific stable complexes with simian virus 40 (SV40) large-T antigen and an adenovirus E1b protein of relat...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Survival
- Cell Transformation, Neoplastic
- DNA
- Enhancer Elements, Genetic
- Mice
- Mutation
- Neoplasm Proteins
- Oncogenes
- Phosphoproteins
- Promoter Regions, Genetic
- Rats
- Transfection
- Tumor Suppressor Protein p53