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Immortalization and malignant transformation of eukaryotic cells.

TSitologiia i genetika - 1 Jan 2000

Stepanenko A A, Kavsan V M

Abstract excerpt

The process of cellular transformation has been amply studied in vitro using immortalized cell lines. Immortalized cells never have the normal diploid karyotype, nevertheless, they cannot grow over one another in cell culture (contact inhibition), do not form colonies in soft agar (anchorage-dependent growth) and do not form tumors when injected into immunodeficient rodents. All these characteristics can be...

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PMID: 22679821

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