Extended lifespan and immortalization of human fibroblasts induced by X-ray irradiation.

doi:10.1002/(sici)1098-2744(199701)18:1<7::aid-mc2>3.0.co;2-f

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Article

Extended lifespan and immortalization of human fibroblasts induced by X-ray irradiation.

Molecular carcinogenesis - 1 Jan 1997

Tsutsui T, Tanaka Y, Matsudo Y, Hasegawa K, Fujino T, Kodama S, Barrett J C

Abstract excerpt

The induction of immortalization of human fibroblasts by carcinogens is a very rare process. Hybrids between immortal cells and normal fibroblasts senesce, indicating that immortal cells must lose one or more senescence genes for immortalization. To examine the possible involvement of multiple ge...

Topics

Adult
Cell Division
Cell Line
Cell Survival
Cell Transformation, Neoplastic
Chromosome Aberrations
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 6
DNA Fingerprinting
Fibroblasts
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Karyotyping

Li-Fraumeni Syndrome

Male

Mutation

Source

Open in PubMed

Identifiers

PMID: 9022808
DOI: 10.1002/(sici)1098-2744(199701)18:1<7::aid-mc2>3.0.co;2-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9022808-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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