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Article

Extended lifespan and immortalization of human fibroblasts induced by X-ray irradiation.

Molecular carcinogenesis - 1 Jan 1997

Tsutsui T, Tanaka Y, Matsudo Y, Hasegawa K, Fujino T, Kodama S, Barrett J C

Abstract excerpt

The induction of immortalization of human fibroblasts by carcinogens is a very rare process. Hybrids between immortal cells and normal fibroblasts senesce, indicating that immortal cells must lose one or more senescence genes for immortalization. To examine the possible involvement of multiple gene alterations in extended lifespan or immortalization of normal human fibroblasts, normal human fibroblasts (WHE-7...

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Source

Identifiers

PMID: 9022808
DOI: 10.1002/(sici)1098-2744(199701)18:1<7::aid-mc2>3.0.co;2-f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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